OIST is one of the boldest initiatives in global research and education of the 21st century. From the outset, we have pursued high ambitions to become established as one of the world’s great scientific research universities. The Japanese Government tasked us with a clear vision to create an international, interdisciplinary university producing new discoveries, breakthrough innovation, and future leaders for a rapidly changing world and workplace. To succeed, we have to hire the best people in the world. Ultimately the reputation of a university is created by the excellence of its faculty, its students, and its staff and management. Our professors form research units that are reasonably small but which work in a larger context of support from the whole university. Here, researchers and graduate students have the opportunity and encouragement to establish multidisciplinary contacts and collaborations. Stable ‘high-trust’ funding, with periodic peer review by world-class experts, is the foundation for our success.